San Diego is a city in the U.S. state of California on the coast of the Pacific Ocean and immediately adjacent to the Mexican border. The city is known for its mild year-round climate, natural deep-water harbor, extensive beaches and parks, long association with the United States Navy and Marine Corps, and recent emergence as a healthcare and biotechnology development center.

The culture of San Diego, California is influenced heavily by the mixing of American and Mexican cultures, due to the city's position on the Mexican-American border, its large Chicano population, and its history as part of Hispanic America and Mexico. San Diego's longtime association with the U.S. military also contributes to its culture.

Many popular museums, such as the San Diego Museum of Art, the San Diego Natural History Museum, the Museum of Us, the Museum of Photographic Arts, and the San Diego Air & Space Museum, are located in Balboa Park, which is also the location of the San Diego Zoo. The Museum of Contemporary Art San Diego (MCASD) is located in La Jolla and has a branch located at the Santa Fe Depot downtown. The downtown branch consists of two buildings on two opposite streets.

The Columbia district downtown is home to historic ship exhibits belonging to the San Diego Maritime Museum, headlined by the Star of India, as well as the unrelated San Diego Aircraft Carrier Museum featuring the USS Midway aircraft carrier.

The San Diego Symphony at Symphony Towers performs on a regular basis; from 2004 to 2017, its director was Jahja Ling. The San Diego Opera at Civic Center Plaza, directed by David Bennett. Old Globe Theatre at Balboa Park produces about 15 plays and musicals annually. The La Jolla Playhouse at UCSD is directed by Christopher Ashley. Both the Old Globe Theatre and the La Jolla Playhouse have produced the world premieres of plays and musicals that have gone on to win Tony Awards or nominations on Broadway. The Joan B. Kroc Theatre at Kroc Center's Performing Arts Center is a 600-seat state-of-the-art theater that hosts music, dance, and theater performances. The San Diego Repertory Theatre at the Lyceum Theatres in Westfield Horton Plaza produces a variety of plays and musicals. Hundreds of movies and a dozen TV shows have been filmed in San Diego, a tradition going back as far as 1898.