Denver, officially the City and County of Denver, is the capital and most populous city of the U.S. State of Colorado. It is located in the South Platte River Valley on the western edge of the High Plains just east of the Front Range of the Rocky Mountains. With an estimated population of 735,538 in 2020, Denver is the 19th-most populous city in the United States, the fifth-most populous state capital, and the most populous city located in the Mountain states. The metropolitan area surrounding Denver represents a majority of the population and economic activity in the Front Range region, the area where an estimated 85% of Colorado's population lives.

Apollo Hall opened soon after the city's founding in 1859 and staged many plays for eager settlers. In the 1880s Horace Tabor built Denver's first opera house. After the start of the 20th century, city leaders embarked on a city beautification program that created many of the city's parks, parkways, museums, and the Municipal Auditorium, which was home to the 1908 Democratic National Convention and is now known as the Ellie Caulkins Opera House. Denver and the metropolitan areas around it continued to support culture.

In July 1982, Denver hosted the World Theatre Festival at the Denver Center for Performing Arts, which comprised a program of 114 performances of 18 plays, by theatre companies from 13 countries, across 25 days.

In 1988, voters in the Denver Metropolitan Area approved the Scientific and Cultural Facilities Tax (commonly known as SCFD), a 0.1% (1 cent per $10) sales tax that contributes money to various cultural and scientific facilities and organizations throughout the Metro area. The tax was renewed by voters in 1994 and 2004 and allowed the SCFD to operate until 2018. Ballot issue 4B in 2016 won approval 62.8 percent to 37.2 percent, by Denver metro area voters, to extend the SCFD sales tax until 2030.

Denver is home to a wide array of museums. Many are nationally recognized, including a new wing for the Denver Art Museum by architect Daniel Libeskind, the nation's second-largest Performing Arts Center after Lincoln Center in New York City, and bustling neighborhoods such as LoDo, filled with art galleries, restaurants, bars and clubs. That is part of the reason Denver was, in 2006, recognized for the third year in a row as the best city for singles. Its neighborhoods also continue their influx of diverse people and businesses while the city's cultural institutions grow and prosper. The city acquired the estate of abstract expressionist painter Clyfford Still in 2004 and built a museum to exhibit his works near the Denver Art Museum. The Denver Museum of Nature and Science holds an aquamarine specimen valued at over $1 million, as well as specimens of the state mineral, rhodochrosite. Every September the Denver Mart, at 451 E. 58th Avenue, hosts a gem and mineral show. The state history museum, History Colorado Center, opened in April 2012. It features hands-on and interactive exhibits, artifacts and programs about Colorado history. It was named in 2013 by True West Magazine as one of the top-ten "must see" history museums in the country. History Colorado's Byers-Evans House Museum and the Molly Brown House are nearby.

Denver has numerous art districts, including Denver's Art District on Santa Fe and the River North Art District (RiNo).

While Denver may not be as recognized for historical musical prominence as some other American cities, it has an active pop, jazz, jam, folk, metal, and classical music scene, which has nurtured several artists and genres to regional, national, and even international attention. Of particular note is Denver's importance in the folk scene of the 1960s and 1970s. Well-known folk artists such as Bob Dylan, Judy Collins and John Denver lived in Denver at various points during this time and performed at local clubs. Three members of the widely popular group Earth, Wind, and Fire are also from Denver. More recent Denver-based artists include India Aire, Nathaniel Rateliff & the Night Sweats, The Lumineers, Air Dubai, The Fray, Flobots, Cephalic Carnage, Axe Murder Boyz, Deuce Mob, Havok, Bloodstrike, Primitive Man, and Five Iron Frenzy.Denver is also home to the Denver Record Collectors Expo, a biannual music collectors event.

Because of its proximity to the mountains and generally sunny weather, Denver has gained a reputation as being a very active, outdoor-oriented city. Many Denver residents spend the weekends in the mountains; skiing in the winter and hiking, climbing, kayaking, and camping in the summer.

Denver and surrounding cities are home to a large number of local and national breweries. Many of the region's restaurants have on-site breweries, and some larger brewers offer tours, including Coors and New Belgium Brewing Company. The city also welcomes visitors from around the world when it hosts the annual Great American Beer Festival each fall.

Denver used to be a major trading center for beef and livestock when ranchers would drive (or later transport) cattle to the Denver Union Stockyards for sale. As a celebration of that history, for more than a century Denver has hosted the annual National Western Stock Show, attracting as many as 10,000 animals and 700,000 attendees. The show is held every January at the National Western Complex northeast of downtown.

Denver has one of the country's largest populations of Mexican Americans and hosts four large Mexican American celebrations: Cinco de Mayo (with over 500,000 attendees), in May; El Grito de la Independencia, in September; the annual Lowrider show, and the Dia De Los Muertos art shows/events in North Denver's Highland neighborhood, and the Lincoln Park neighborhood in the original section of West Denver.

Denver is known for its dedication to New Mexican cuisine and the chile. It is best known for its green and red chile sauce, Colorado burrito, Southwest (Denver) omelette, breakfast burrito, empanadas, chiles rellenos, and tamales. Denver is also known for other types of food such as Rocky Mountain oysters, rainbow trout, and the Denver sandwich.

The Dragon Boat Festival in July, Moon Festival in September and Chinese New Year are annual events in Denver for the Chinese and Asian-American communities. Chinese hot pot (huo guo) and Korean BBQ restaurants have been growing in popularity. The Denver area has two Chinese newspapers, the Chinese American Post and the Colorado Chinese News. A Korean Newspaper, the "Colorado Times News" is also based in Denver.

Denver has long been a place tolerant of the Lesbian, Gay, Bisexual, Transgender, and Queer (LGBTQ) community. Many gay bars can be found on Colfax Avenue and on South Broadway. Every June, Denver hosts the annual Denver PrideFest in Civic Center Park, the largest LGBTQ Pride festival in the Rocky Mountain region.

Denver is the setting for The Bill Engvall Show, Tim Allen's Last Man Standing and the 18th season of MTV's The Real World. It was also the setting for the prime time drama Dynasty from 1981 to 1989 (although the show was mostly filmed in Los Angeles). From 1998 to 2002 the city's Alameda East Veterinary Hospital was home to the Animal Planet series Emergency Vets, which spun off three documentary specials and the current Animal Planet series E-Vet Interns. The city is also the setting for the Disney Channel sitcom Good Luck Charlie.